6-Hydroxydiscodermindole, A New Discodermindole from the Marine Sponge Discodermia polydiscus

6-Hydroxydiscodermindole (2), a new discodermindole analogue, has been isolated from the deep-water marine sponge Discodermia polydiscus. It showed marginal in vitro cytotoxicity against cultured murine P388 leukemia cells. The isolation, structure elucidation and cytotoxicity of 6-hydroxydiscodermindole (2) is described.

This author manuscript is an electronic version of an article published in Pharmaceutical Biology and may be cited as Cohen, Jesse, Gopal K. Paul, Sarath P. Gunasekera, Ross E. Longley and Shirley A. Pomponi (2004) 6-Hydroxydiscodermindole, A New Discodermindole from the Marine Sponge Discodermia polydiscus, Pharmaceutical Biology 42(1):59–61.

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1551.