Acetylated analogues of the microtubule stabilizing agent Discodermolide: preparation and biological activity

A series of eight discodermolide acetates have been prepared using natural (+)-discodermolide and evaluated for in vitro cytotoxicity against the cultured murine P-388 leukemia cells. The acetylated analogues showed a significant variation of cytotoxicity and suggested the importance of C-11 and C-17 hydroxyl groups for potency. The preparation and structure elucidation of the new analogues are described.

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np000423e. This article may be cited as: Gunasekera, S. P., Longley, R. E., & Isbrucker, R. A. (2001). Acetylated analogues of the microtubule stabilizing agent Discodermolide: preparation and biological activity. Journal of Natural Products, 64(2), 171-174. doi:10.1021/np000423e

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1388.