The immune competence of green sea turtles (Chelonia mydas) with fibropapillomatosis was assessed using in vitro techniques to measure lymphocyte proliferation in response to mitogens. In comparison with captive, healthy green sea turtles, those afflicted with fibropapillomas demonstrated diminished proliferation with Concanavalin A, phytohemagglutinin (T-cell mitogens), and lipopolysaccharide (B-cell mitogen). Also, markedly decreased proliferative responses to the lymphocyte polyclonal stimulator combination of ionomycin and phorbol myristate acetate were observed. Total circulating white blood cell counts were not statistically different between the two groups, although an overall decrease in lymphocyte number was observed in the papilloma group. The albumin/globulin ratio was decreased in the papilloma group because of decreased albumin and increased gamma globulins.
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Publisher
American Association of Zoo Veterinarians
Date Issued
2001
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Language
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Form
Extent
6 p.
Subject (Topical)
Identifier
FA00007242
Additional Information
The immune competence of green sea turtles (Chelonia mydas) with fibropapillomatosis was assessed using in vitro techniques to measure lymphocyte proliferation in response to mitogens. In comparison with captive, healthy green sea turtles, those afflicted with fibropapillomas demonstrated diminished proliferation with Concanavalin A, phytohemagglutinin (T-cell mitogens), and lipopolysaccharide (B-cell mitogen). Also, markedly decreased proliferative responses to the lymphocyte polyclonal stimulator combination of ionomycin and phorbol myristate acetate were observed. Total circulating white blood cell counts were not statistically different between the two groups, although an overall decrease in lymphocyte number was observed in the papilloma group. The albumin/globulin ratio was decreased in the papilloma group because of decreased albumin and increased gamma globulins.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1493
This manuscript is an author version with
the final publication available and may be cited as: Cray, C., Varela, R., Bossart, G. D., & Lutz, P. (2001).
Altered in vitro immune responses in green turtles (Chelonia mydas) with fibropapillomatosis. Journal
of Zoo and Wildlife Medicine, 32(4), 436-440.
the final publication available and may be cited as: Cray, C., Varela, R., Bossart, G. D., & Lutz, P. (2001).
Altered in vitro immune responses in green turtles (Chelonia mydas) with fibropapillomatosis. Journal
of Zoo and Wildlife Medicine, 32(4), 436-440.
Date Backup
2001
Date Text
2001
Date Issued (EDTF)
2001
Extension
FAU
IID
FA00007242
Organizations
Attributed name: Bossart, Gregory D.
Attributed name: Harbor Branch Oceanographic Institute
Person Preferred Name
Cray, C.
Physical Description
6 p.
Title Plain
Altered in vitro immune responses in green turtles (Chelonia mydas) with fibropapillomatosis
Origin Information
2001
American Association of Zoo Veterinarians
Lawrence, KS
Place
Lawrence, KS
Title
Altered in vitro immune responses in green turtles (Chelonia mydas) with fibropapillomatosis
Other Title Info
Altered in vitro immune responses in green turtles (Chelonia mydas) with fibropapillomatosis