Antitumor cyclic peroxides from the sponge Plakortis lita

Member of
HBOI Faculty Contributions
Contributors
Sakemi, S.
Higa, T.
Anthoni, U.
Christophersen, C.
Publisher
Elsevier
Date Issued
1987
Note

Four new cyclic peroxides (5–8) along with known chondrillin (4) have been isolated as antitumor constituents of the sponge Plakortis lita. These are methyl-(3S*, 6S*)-3, 6-epidioxy- 6-methoxyoctadec-4-enoate (5), methyl( 3S*, 6S*, 16E)-3, 6-epidoxy- 6-methoxyoctadeca-4,16-dienoate (6), methyl( 3S*, 6S*, 14E, 16E)- 3, 6-epidioxy-6-methoxyoctadeca-4, 14, 16-trienoate (7), and methyl-( 3S*, 6S*, 16E, 18E)-3, 6-epidioxy-6-methoxyeicosa-4 ,16 ,18- trinoate (8). All of them are epimeric to 4 and exhibit higher antitumor potency than 4.

Language
English
Type
Text
Genre
article
Extent
7 p.
Subject (Topical)
Antineoplastic agents
Sponges
Peroxides
Marine metabolites
Identifier
3353800
Additional Information
Four new cyclic peroxides (5–8) along with known chondrillin (4) have been isolated as antitumor constituents of the sponge Plakortis lita. These are methyl-(3S*, 6S*)-3, 6-epidioxy- 6-methoxyoctadec-4-enoate (5), methyl( 3S*, 6S*, 16E)-3, 6-epidoxy- 6-methoxyoctadeca-4,16-dienoate (6), methyl( 3S*, 6S*, 14E, 16E)- 3, 6-epidioxy-6-methoxyoctadeca-4, 14, 16-trienoate (7), and methyl-( 3S*, 6S*, 16E, 18E)-3, 6-epidioxy-6-methoxyeicosa-4 ,16 ,18- trinoate (8). All of them are epimeric to 4 and exhibit higher antitumor potency than 4.
The final published version of this manuscript is available at http://www.sciencedirect.com/science/journal/00404020 and may be cited as: Sakemi, S., Higa, T., Anthoni, U., & Christophersen, C. (1987). Antitumor cyclic peroxides from the sponge Plakortis lita. Tetrahedron, 43(1), 263-268. doi:10.1016/S0040-4020(01)89953-1
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #577.
Date Backup
1987
Date Text
1987
DOI
10.1016/S0040-4020(01)89953-1
Date Issued (EDTF)
1987
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing13930", creator="creator:BCHANG", creation_date="2012-10-29 12:10:59", modified_by="super:FAUDIG", modification_date="2014-02-05 13:55:50"

IID
FADT3353800
Issuance
single unit
Organizations
Attributed name: Harbor Branch Oceanographic Institute
Person Preferred Name

Sakemi, S.

creator

Physical Description

pdf
7 p.
PURL
http://purl.flvc.org/FCLA/DT/3353800
Title Plain
Antitumor cyclic peroxides from the sponge Plakortis lita
URL
http://purl.flvc.org/FCLA/DT/3353800
Origin Information

Elsevier
1987
single unit
Title
Antitumor cyclic peroxides from the sponge Plakortis lita
Other Title Info

Antitumor cyclic peroxides from the sponge Plakortis lita