Aplysillin A, a thrombin receptor antagonist from the marine sponge, Aplysina fistularis fulva

Aplysillin A [1], an unusual disulfate ester of a 1,4-diphenyl-1,3-butadiene, was isolated from a deep water specimen of a sponge of the genus Aplysina. Its structure was determined through spectroscopic methods. The compound weakly inhibited binding to the thrombin receptor with an IC50 value of 20 microM.

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50120a023. This article may be cited as: Gulavita, N. K., Pomponi, S. A., Wright, A. E., Garay, M., & Sills, M. A. (1995). Aplysillin A, a thrombin receptor antagonist from the marine sponge, Aplysina fistularis fulva. Journal of Natural Products, 58(6), 954-957. doi:10.1021/np50120a023

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1078.