Bioassay-guided isolation and identification of linoleic acid: A guanosine diphosphate/G-protein RASexchange (GDPX) inhibitor from Aspergillus

An extract of an Aspergillus sp. (HBOI strain D245) was found to inhibit guanosine diphosphate/G-protein RAS exchange (GDPX). Bioassay-guided purification led to the isolation of linoleic acid (1). 1 gave significant inhibition in the GDPX assay, while methyl linoleate (2) was inactive. In this paper we report the isolation, identification and biological activity of 1.Read More: http://informahealthcare.com/doi/abs/10.3109/13880209509065375

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1048

This manuscript is an author version with the final publication
available and may be cited as: Gunasekera, S. P., Sennett, S. H., Janda, K. E., & Bryant, R. W. (1995).
Bioassay-guided isolation and identification of linoleic acid: A guanosine diphosphate/G-protein RAS
exchange (GDPX) inhibitor from Aspergillus. International Journal of Pharmacognosy 33(3), 256-258.