Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2018
EDTF Date Created
2018
Description
Aging is the number one risk factor for numerous chronic diseases driving increased morbidity and healthcare costs globally. Thus, finding ways to uncouple chronical aging with risk of disease is imperative. Extensive evidence links aging with increased oxidative stress. The free radical theory of aging posits that reactive oxygen species (ROS) increase with age and cause oxidative damage to cellular components, thereby driving aging. In support of this, overexpressing the endogenous antioxidant catalase specifically in mitochondria (mCAT transgene) improves health and lifespan of mice. I hypothesized that if ROS is a root cause of aging then the mCAT transgene would slow aging in a murine model of a human progeroid syndrome (Ercc1-/Δ mice). Unfortunately, mCAT expression was not highly expressed in all tissues. Nevertheless, mCAT+/-;Ercc1-/Δ mice showed improvements in functional tests and health evaluations relative to Ercc1-/Δ mice supporting the conclusion that ROS plays an important causal role in aging.
matching, pre-transplant assessments and allocation of organs. In addition, I will discuss
ethical principles that can be used to aid transplant teams in the difficult task of allocating of
organs. I will also evaluate alternative options to the current transplant process such as an
opt-out vs. an opt-in system and controlled financial payment for organs. Finally, I will
analyze current policies regarding living donors and suggest avenues for future research into
alternative resources for organs.
matching, pre-transplant assessments and allocation of organs. In addition, I will discuss
ethical principles that can be used to aid transplant teams in the difficult task of allocating of
organs. I will also evaluate alternative options to the current transplant process such as an
opt-out vs. an opt-in system and controlled financial payment for organs. Finally, I will
analyze current policies regarding living donors and suggest avenues for future research into
alternative resources for organs.
Language
Type
Genre
Form
Extent
33 p.
Identifier
FAUHT00016
Additional Information
Includes bibliography.
Thesis (B.A.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2018.
FAU Honors Theses Digital Collection
Date Backup
2018
Date Created Backup
2018
Date Text
2018
Date Created (EDTF)
2018
Date Issued (EDTF)
2018
Extension
FAU
IID
FAUHT00016
Organizations
Attributed name: Florida Atlantic University
Attributed name: Harriet L. Wilkes Honors College
Person Preferred Name
Frydman, Sylvia
author
Physical Description
application/pdf
33 p.
Title Plain
BIOLOGICAL BENEFIT OF THE MCAT TRANSGENE IN PROGEROID MICE
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Origin Information
2018
2018
Florida Atlantic University
Jupiter, Florida
Physical Location
Florida Atlantic University Libraries
Place
Jupiter, Florida
Sub Location
Digital Library
Title
BIOLOGICAL BENEFIT OF THE MCAT TRANSGENE IN PROGEROID MICE
Other Title Info
BIOLOGICAL BENEFIT OF THE MCAT TRANSGENE IN PROGEROID MICE