A brominated (aminoimidazolinyl) indole from the sponge Discodermia polydiscus

A wide variety of bioactive imidazole alkaloids derived from aromatic amino acids were reported from marine invertebrates.1 Representative structures included aplysinopsins,2 topsentins,3 polyandrocarpamide D,4 and naamidines.5 During the course of our search for antitumor compounds from marine organisms, we isolated a novel brominated (aminoimidazolinyl)indole, designated as discodermindole (l), from the sponge Discodermia polydiscus DuBocage 1879 (family Theonellidae, order Lithistida).6

This document is the accepted manuscript version of a published work that appeared in final form in The Journal of Organic Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo00013a045. This article may be cited as: Sun, H. H., & Sakemi, S. (1991). A brominated (aminoimidazolinyl) indole from the sponge Discodermia polydiscus. The Journal of Organic Chemistry, 56(13), 4307-4308. doi:10.1021/jo00013a045

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #836.