The characterization of both glial and neuronal mechanisms in the modulation of neuroprotection via the PKG pathway

Previous work demonstrates that PKG pathway modulation in Drosophila controls
tolerance to stress in adults and larvae. Through the use of genetics and pharmacology, PKG
inhibition leads to significant protection of function while activation causes increased sensitivity
and early coma onset. In this study we investigate the effect of PKG modulation on neurons and
glia during acute hyperthermia, and begin to determine the underlying physiological
contributions of both tissues.
Glia have been found to influence single neuron activity and global brain function. Neurons, the
most energy-demanding cells in our bodies, are most sensitive to stress. As humans, our neurons
function under stress until permanent failure, resulting in brain damage and even death. Insects
are much more tolerant to environmental stressors. Although stress-activated protective
pathways are highly conserved in both insects and humans, their outcome on neuronal function
and survival are very different.