Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2013
EDTF Date Created
2013
Description
Dysfunction of GABAB-receptor (GABAB-R)-mediated synaptic transmission underlies various nervous system disorders including epilepsy, depression, schizophrenia, and addiction. Currently, only one GABAB-R orthosteric ligand is in clinical use. However, side effects such as sedation, tolerance, and motor impairment limit its use. A dissociation of the therapeutic effects from the side effects may be achievable with drugs enhancing the endogenous physiological cellular response. The development of GABAB-R allosteric modulators has provided new modes of efficacy that may facilitate the development of novel therapeutic agents. In the present study, we investigated the effects of novel, newly synthesized GABAB-R allosteric ligands using a HEK-293 cell line stably expressing human GABAB1(b)/human GABAB(2) subunits using a cell-based cAMP HTRF assay. One compound was identified and characterized as a potential novel GABAB-R positive allosteric modulator (PAM), and will be subjected to further in vitro and in vivo analyses.
Language
Type
Genre
Form
Extent
47 p.
Identifier
FA00003502
Rights
Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Additional Information
Includes bibliography.
Thesis (B.S.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2013.
Date Backup
2013
Date Created Backup
2013
Date Text
2013
Date Created (EDTF)
2013
Date Issued (EDTF)
2013
Extension
FAU
IID
FA00003502
Organizations
Attributed name: Harriet L. Wilkes Honors College
Person Preferred Name
Aitken, Maria de Lourdes
Physical Description
47 p.
born digital
Title Plain
Development of cell-based functional assays to identify and characterize novel GABAb receptor allosteric modulators
Use and Reproduction
Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Digital Origin
born digital
Origin Information
2013
2013
Florida Atlantic University
Boca Raton, Florida
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Florida
Sub Location
FAU Digital Library
Title
Development of cell-based functional assays to identify and characterize novel GABAb receptor allosteric modulators
Other Title Info
Development of cell-based functional assays to identify and characterize novel GABAb receptor allosteric modulators