Computer-assisted structure analysis indicated (+)-discodermolide, a polyhydroxylated alkatetraene lactone marine natural product, was an antimitotic compound, and we confirmed this prediction. Previous work had shown an accumulation of discodermolide-treated cells in the G2/M portion of the cell cycle, and we have now found that discodermolide arrests Burkitt lymphoma cells in mitosis.
This document is the accepted manuscript version of a published work that appeared in final form in Biochemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/bi9515127. This article may be cited as: Haar, E., Kowalski, R. J., Hamel, E., Lin, C. M., Longley, R. E., Gunasekera, S. P., Rosenkranz, H. S., & Day, B. W. (1996). Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. Biochemistry, 35(1), 243-250. doi:10.1021/bi9515127
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1123.