Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella

Discorhabdin P (1), a new discorhabdin analogue, has been isolated from a deep-water marine sponge of the genus Batzella. Discorhabdin P (1) inhibited the phosphatase activity of calcineurin and the peptidase activity of CPP32. It also showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of discorhabdin P (1) are described.

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np980293y. This article may be cited as: Gunasekera, S. P., McCarthy, P. J., Longley, R. E., Pomponi, S. A., Wright, A. E., Lobkovsky, E., & Clardy, J. (1999). Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella. Journal of Natural Products, 62(1), 173-175. doi:10.1021/np980293y

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1260.