Diterpene metabolites from two chemotypes of the marine sponge Myrmekioderma styx

Three apparent chemotypes of the marine sponge Myrmekioderma styx exist. An acyclic diterpene, styxenol A [1], has been isolated from the shallow water chemotype, while three tricarbocyclic diterpenes 3, 6, and 7 have been isolated from the deep chemotype. The structures were elucidated based on spectral methods including homo- and hetero-nuclear 2D nmr experiments. Compounds 1, 3, and 6 exhibit moderate cytotoxicity against the P-388 murine leukemia cell line and the A549 human lung tumor cell line.

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50088a006. This article may be cited as: Sennett, S. H., Pomponi, S. A., & Wright, A. E. (1992). Diterpene metabolites from two chemotypes of the marine sponge Myrmekioderma styx. Journal of Natural Products, 55(10), 1421-1429. doi:10.1021/np50088a006

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #924.