Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2016
EDTF Date Created
2016
Description
The purpose of this study was to determine if maximal aerobic exercise promotes
BDNF expression in obese individuals. Plasma levels and the expression of BDNF in
PBMCs were examined. 22 participants (10 obese, 12 non-obese) completed a V02max
treadmill test and blood was obtained pre, post, and 1 and 2 hours into exercise recovery.
Plasma and PBMCs were isolated and analyzed for BDNF via ELISA and Western blot
techniques. A significant effect for time was observed for plasma BDNF (P= <0.00 1 ).
Additionally, A significant group-by-time interaction was found from pre-to-RIH for
BDNF expression in PBMCs (P= 0.046). Further, significant correlations were found
between BMI and waist circumference (r= .91, P< 0.001), WHR (r= .51, P= 0.002) and
Pre-to-RlH ratio (r=0.58, P=0.008). Young obese subject's BDNF response to maximal
exercise was consistent with previous studies. Post-exercise BDNF expressed in PBMCs
were significantly higher than rest suggesting immunological-neuroprotective
interactions in the CNS.
BDNF expression in obese individuals. Plasma levels and the expression of BDNF in
PBMCs were examined. 22 participants (10 obese, 12 non-obese) completed a V02max
treadmill test and blood was obtained pre, post, and 1 and 2 hours into exercise recovery.
Plasma and PBMCs were isolated and analyzed for BDNF via ELISA and Western blot
techniques. A significant effect for time was observed for plasma BDNF (P= <0.00 1 ).
Additionally, A significant group-by-time interaction was found from pre-to-RIH for
BDNF expression in PBMCs (P= 0.046). Further, significant correlations were found
between BMI and waist circumference (r= .91, P< 0.001), WHR (r= .51, P= 0.002) and
Pre-to-RlH ratio (r=0.58, P=0.008). Young obese subject's BDNF response to maximal
exercise was consistent with previous studies. Post-exercise BDNF expressed in PBMCs
were significantly higher than rest suggesting immunological-neuroprotective
interactions in the CNS.
Language
Type
Form
Extent
58 p.
Subject (Topical)
Identifier
FA00004664
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2016.
FAU Electronic Theses and Dissertations Collection
Date Backup
2016
Date Created Backup
2016
Date Text
2016
Date Created (EDTF)
2016
Date Issued (EDTF)
2016
Extension
FAU
IID
FA00004664
Organizations
Attributed name: Florida Atlantic University
Attributed name: College of Education
Attributed name: Department of Exercise Science and Health Promotion
Person Preferred Name
Maharaj, Arun
author
Graduate College
Physical Description
application/pdf
58 p.
Title Plain
The Effect of Maximal Aerobic Exercise on Plasma BDNF and BDNF Expression in PBMCs in Obese and Non-Obese Individuals
Use and Reproduction
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Origin Information
2016
2016
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
The Effect of Maximal Aerobic Exercise on Plasma BDNF and BDNF Expression in PBMCs in Obese and Non-Obese Individuals
Other Title Info
The Effect of Maximal Aerobic Exercise on Plasma BDNF and BDNF Expression in PBMCs in Obese and Non-Obese Individuals