Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2007
EDTF Date Created
2007
Description
Unlike most neurons in the adult nervous system, olfactory receptor neurons (ORN),
found in the olfactory epithelium (OE), continually turnover in the adult rat. These
neurons project their axons to the olfactory bulb which is their central target. The
present study eliminated target neurons in the bulb using N-methyl-D-aspartate
(NMDA) to examine the effects of target loss on ORN survival and maturation. We
compared the effects of the NMDA lesion to bulbectomy, a permanent surgical
removal of the bulb, which simultaneously causes damage to ORN axons. We found
that unlike bulbectomy, large numbers of dying OE cells were not observed at any
time after the lesion. The number of immature neurons increased relative to the
control side, and the number of mature neurons also slightly increased with time
following NMDA lesion. Survival of ORNs does not seem to be significantly altered
in the absence of its target.
found in the olfactory epithelium (OE), continually turnover in the adult rat. These
neurons project their axons to the olfactory bulb which is their central target. The
present study eliminated target neurons in the bulb using N-methyl-D-aspartate
(NMDA) to examine the effects of target loss on ORN survival and maturation. We
compared the effects of the NMDA lesion to bulbectomy, a permanent surgical
removal of the bulb, which simultaneously causes damage to ORN axons. We found
that unlike bulbectomy, large numbers of dying OE cells were not observed at any
time after the lesion. The number of immature neurons increased relative to the
control side, and the number of mature neurons also slightly increased with time
following NMDA lesion. Survival of ORNs does not seem to be significantly altered
in the absence of its target.
Language
Type
Form
Extent
60 p.
Subject (Topical)
Identifier
FA00000838
Additional Information
Includes bibliography.
Thesis (M.S.)--Florida Atlantic University, 2007.
FAU Electronic Theses and Dissertations Collection
Charles E. Schmidt College of Medicine
Date Backup
2007
Date Created Backup
2007
Date Text
2007
Date Created (EDTF)
2007
Date Issued (EDTF)
2007
Extension
FAU
IID
FA00000838
Organizations
Attributed name: Florida Atlantic University
Person Preferred Name
Sultan, Krista K.
Graduate College
Physical Description
application/pdf
60 p.
Title Plain
Effects of Target Neuron Loss on Olfactory Receptor Neurons in the Adult Rat
Use and Reproduction
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Origin Information
2007
2007
Florida Atlantic University
Boca Raton, Fla.
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Fla.
Sub Location
Digital Library
Title
Effects of Target Neuron Loss on Olfactory Receptor Neurons in the Adult Rat
Other Title Info
Effects of Target Neuron Loss on Olfactory Receptor Neurons in the Adult Rat