FAU College Collections
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Intestinal autophagy activity is essential for host defense against Salmonella typhimurium infection in Caenorhabditis elega
Type: Text
Year: 2014, 2014
Member of: FAU College Collections
Contributors: Alexander Curt, Jiuli Zhang, Justin Minnerly, Kailiang Jia
Publisher: Elsevier
Description: Salmonella typhimurium infects both intestinal epithelial cells and macrophages. Autophagy is a lysosomal
degradation pathway that is present in all eukaryotes. Autophagy has been reported to limit the
Salmonella replication in Caenorhabditis elegans and in mammals. However, it is unknown whether intestinal
autophagy activity plays a role in host defense against Salmonella infection in C.… more
Full Text: Developmental and Comparative Immunology 45 (2014) 214–218 Contents lists available at ScienceDirect Developmental and Comparative Immunology journal homepage: www.elsevier.com/locate/dci Short communication Intestinal autophagy activity is essential for …
Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficien
Type: Text
Year: 2014, 2014
Member of: FAU College Collections
Contributors: Christopher E. Carr, Daniel J. Klionsky, Jennifer L. Johnson, Jie Qi, Kailiang Jia, Matthew Gill, Patrick Kobler, Peter E. Bayliss, Sergio D. Catz, Shanshan Lian, Sujay Guha, Tomoyuki Sasaki
Publisher: Public Library of Science
Description: Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H+-carbohydrate
transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces aberrant autolysosome formation that leads to embryonic senescence and accelerated aging symptoms, but little is known about the mechanisms leading to the pathogenesis in vivo. Beclin 1 and p53… more
Full Text: Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency Tomoyuki Sasaki1, Shanshan Lian1, Jie Qi1¤, Peter E. Bayliss2, Christopher E. Carr3, Jennifer L. …
A Protocol to Infect Caenorhabditis elegans with Salmonella typhimuri
Type: Text
Year: 2014, 2014
Member of: FAU College Collections
Contributors: Jiuli Zhang, Kailiang Jia
Publisher: MyJove Corporation
Description: In the last decade, C. elegans has emerged as an invertebrate organism to study interactions between hosts and pathogens, including the host defense against gram-negative bacterium Salmonella typhimurium. Salmonella establishes persistent infection in the intestine of C. elegans and results in early death of infected animals. A number of immunity mechanisms have been identified in C. elegans to… more
Full Text: Journal of Visualized Experiments www.jove.com Video Article A Protocol to Infect Caenorhabditis elegans with Salmonella typhimurium 1 1 Jiuli Zhang , Kailiang Jia 1 Department of Biological Sciences, Florida Atlantic University Correspondence to: …