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Genetic Variation Shapes Protein Networks Mainly through Non-transcriptional Mechanisms

Type: Text

Year: 2011, 2011

Member of: FAU College Collections

Contributors: Bedalov, Antonio, Eisen, Michael B., Foss, Eric J., Goodlett, David R., Kruglyak, Leonid, Radulovic, Dragan, Shaffer, Scott A.

Description: Networks of co-regulated transcripts in genetically diverse populations have been studied extensively, but little is known about the degree to which these networks cause similar co-variation at the protein level. We quantified 354 proteins in a genetically diverse population of yeast segregants, which allowed for the first time construction of a coherent protein covariation matrix. We… more

Full Text: Genetic Variation Shapes Protein Networks Mainly through Non-transcriptional Mechanisms Eric J. Foss1, Dragan Radulovic2*, Scott A. Shaffer3, David R. Goodlett4, Leonid Kruglyak5, Antonio Bedalov1* 1 Clinical Research Division, Fred Hutchinson Cancer …