FAU College Collections
Displaying 1 - 18 of 18
Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics
Type: Text
Year: 2002, 2002
Member of: FAU College Collections
Contributors: Brew, Keith, Nagase, Hideaki
Description: Matrix metalloproteinases (MMPs) play a central role in many biological processes such as development, morphogenesis and wound healing, but their unbalanced activities are implicated innumerous disease processes such as arthritis, cancer metastasis, atherosclerosis, nephritis and fibrosis. One of the key mechanisms to control MMP activities is inhibition by endogenous inhibitors called tissue… more
Full Text: Available online http://arthritis-research.com/content/4/S3/S051 Supplement Review Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics Hideaki Nagase* and Keith Brew† *The Kennedy Institute of Rheumatology Division, …
Characterization of a Metal-independent CAZy Family 6 Glycosyltransferase from Bacteroides ovatus
Type: Text
Year: 2009, 2009
Member of: FAU College Collections
Contributors: Brew, Keith, Tumbale, Percy
Full Text: JBC Papers in Press. Published on July 21, 2009 as Manuscript M109.033878 The latest version is at http://www.jbc.org/cgi/doi/10.1074/jbc.M109.033878 Characterization of a Metal-Independent CAZy Family 6 Glycosyltransferase from Bacteroides ovatus Percy …
A New Role for TIMP-1 in Modulating Neurite Outgrowth and Morphology of Cortical Neurons
Type: Text
Year: 2009, 2009
Member of: FAU College Collections
Contributors: Bernard, Anne, Brew, Keith, Charrat, Eliane, Chédotal, Alain, Dive, Vincent, Ferhat, Lotfi, Gueye, Yatma, Khrestchatisky, Michel, Lim, Ngee Han, Ould-yahoui, Adlane, Risso, Jean-Jacques, Rivera, Santiago, Sbai, Oualid, Tremblay, Evelyne
Full Text: A New Role for TIMP-1 in Modulating Neurite Outgrowth and Morphology of Cortical Neurons Adlane Ould-yahoui1, Evelyne Tremblay1, Oualid Sbai1, Lotfi Ferhat1, Anne Bernard1, Eliane Charrat1, Yatma Gueye1, Ngee Han Lim2, Keith Brew3, Jean-Jacques Risso4, …
Phage Display of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2)
Type: Text
Year: 2011, 2011
Member of: FAU College Collections
Contributors: Bahudhanapati, Harinath, Brew, Keith, Sidhu, Sachdev S., Zhang, Yingnan
Full Text: JBC Papers in Press. Published on June 29, 2011 as Manuscript M111.253328 The latest version is at http://www.jbc.org/cgi/doi/10.1074/jbc.M111.253328 Phage display of Tissue Inhibitor of Metalloproteinases-2 (TIMP-2): Identification of selective …
The Roles of Substrate Thermal Stability and P2 and P1′ Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity
Type: Text
Year: 2006, 2006
Member of: FAU College Collections
Contributors: Brew, Keith, Cudic, Mare, Fields, Gregg B., Lauer-Fields, Janelle L., Minond, Dmitriy, Nagase, Hideaki, Overall, Christopher M., Pei, Duanqing, Visse, Robert
Full Text: THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 281, NO. 50, pp. 38302–38313, December 15, 2006 © 2006 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in the U.S.A. The Roles of Substrate Thermal Stability and P2 and P1ⴕ Subsite …
Characterization of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis
Type: Text
Year: 2007, 2007
Member of: FAU College Collections
Contributors: Acharya, K. Ravi, Brew, Keith, Crabtree, Benedict, Ferns, Tyrone, Iyer, Shalini, Prior, Stephen H., Shapiro, Robert, Subramanian, Vasanta, Thiyagarajan, Nethaji, Wilson, Peter
Full Text: 11810 Biochemistry 2007, 46, 11810-11818 Characterization of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis† Benedict Crabtree,‡ Nethaji Thiyagarajan,‡ Stephen H. Prior,‡,§ Peter Wilson,‡ Shalini Iyer,‡ Tyrone Ferns,| Robert …
Inactivation of N-TIMP-1 by N-terminal acetylation when expressed in bacteria
Type: Text
Year: 2008, 2008
Member of: FAU College Collections
Contributors: Bahudhanapati, Harinath, Brew, Keith, DaGue, Beverly B., Gao, Guanghua, Palmier, Mark O., Van Doren, Steven R., Wei, Shuo
Full Text: NIH Public Access Author Manuscript Biopolymers. Author manuscript; available in PMC 2010 January 11. NIH-PA Author Manuscript Published in final edited form as: Biopolymers. 2008 November ; 89(11): 960–968. doi:10.1002/bip.21043. Inactivation of N-TIMP-1 …
Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications
Type: Text
Year: 2010, 2010
Member of: FAU College Collections
Contributors: Brew, Keith, Enghild, Jan J., Jones, Jonathan, Kashiwagi, Masahide, Lim, Ngee H., Nagase, Hideaki, Visse, Robert
Full Text: www.biochemj.org Biochem. J. (2010) 431, 113–122 (Printed in Great Britain) 113 doi:10.1042/BJ20100725 Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications Ngee H. LIM*, Masahide …
Thermodynamic Basis of Selectivity in the Interactions of Tissue Inhibitors of Metalloproteinases N-domains with Matrix Metalloproteinases-1, -3, and -14
Type: Text
Year: 2016, 2016
Member of: FAU College Collections
Contributors: Brew, Keith, Wu, Ying, Zou, Haiyin
Full Text: JBC Papers in Press. Published on March 31, 2016 as Manuscript M116.720250 The latest version is at http://www.jbc.org/cgi/doi/10.1074/jbc.M116.720250 Thermodynamics of selectivity in N-TIMP/MMP interactions Thermodynamic basis of selectivity in the …
Hypothesis
Type: Text
Year: 2016, 2016
Member of: FAU College Collections
Contributors: Brew, Keith, Hennekens, Charles H., Lizotte-Waniewski, Michelle
Full Text: Editorial Hypothesis: Metalloproteinase Inhibitors Decrease Risks of Cardiovascular Disease Journal of Cardiovascular Pharmacology and Therapeutics 2016, Vol. 21(4) 368-371 ª The Author(s) 2015 Reprints and permission: sagepub.com/journalsPermissions.nav …
Structures of Complexes of a Metal-independent Glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-Acetylgalactosamine (UDP-GalNAc) and Its Hydrolysis Products
Type: Text
Year: 2014, 2014
Member of: FAU College Collections
Contributors: Acharya, K. Ravi, Brew, Keith, Lizotte-Waniewski, Michelle, Pham, Tram T.K., Stinson, Brittany, Thiyagarajan, Nethaji
Full Text: JBC Papers in Press. Published on January 23, 2014 as Manuscript M113.545384 The latest version is at http://www.jbc.org/cgi/doi/10.1074/jbc.M113.545384 Structure of metal-independent GT6 complexes with donor substrate Structures of Complexes of a …
Tissue inhibitor of metalloproteinases-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: mechanisms and relevance to HIV-1-associated dementia
Type: Text
Year: 2012, 2012
Member of: FAU College Collections
Contributors: Ashutosh, Borgmann, K, Brew, Keith, Chao, C, Ghorpade, A
Full Text: Citation: Cell Death and Disease (2012) 3, e332; doi:10.1038/cddis.2012.54 & 2012 Macmillan Publishers Limited All rights reserved 2041-4889/12 www.nature.com/cddis Tissue inhibitor of metalloproteinases-1 protects human neurons from staurosporine and …
Reflections on the evolution of the vertebrate tissue inhibitors of metalloproteinases
Type: Text
Year: 2019, 2019
Member of: FAU College Collections
Contributors: Brew, Keith
Full Text: THE JOURNAL • REVIEW • www.fasebj.org Reflections on the evolution of the vertebrate tissue inhibitors of metalloproteinases Keith Brew1 Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, …
Entropy Increases from Different Sources Support the High-affinity Binding of the N-terminal Inhibitory Domains of Tissue Inhibitors of Metalloproteinases to the Catalytic Domains of Matrix Metalloproteinases-1 and -3
Type: Text
Year: 2011, 2011
Member of: FAU College Collections
Contributors: Brew, Keith, Van Doren, Steven R., Wei, Shuo, Wu, Ying
Full Text: JBC Papers in Press. Published on March 28, 2011 as Manuscript M111.222307 The latest version is at http://www.jbc.org/cgi/doi/10.1074/jbc.M111.222307 Entropy increases from different sources support the high-affinity binding of the N-terminal inhibitory …
Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen
Type: Text
Year: 2012, 2012
Member of: FAU College Collections
Contributors: Acharya, K. Ravi, Brew, Keith, Lizotte-Waniewski, Michelle, Pham, Tram T. K., Stinson, Brittany, Sundriyal, Amit, Thiyagarajan, Nethaji, Tumbale, Percy
Full Text: SUBJECT AREAS: GLYCOBIOLOGY MECHANISM OF ACTION X-RAY CRYSTALLOGRAPHY ENZYMES Received 12 November 2012 Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen Nethaji Thiyagarajan1, Tram …
Development of a convenient peptide-based assay for lysyl hydroxylase
Type: Text
Year: 2007, 2007
Member of: FAU College Collections
Contributors: Brew, Keith, Cudic, Mare, Fields, Gregg B., Lauer-Fields, Janelle L., Patel, Deepak A.
Full Text: Development of a Convenient Peptide-Based Assay for Development of a Convenient Peptide-Based Assay for Lysyl Hydroxylase Lysyl Hydroxylase Mare Cudic,1 Deepak A. Patel,1 Janelle L. Lauer-Fields,1,2 Keith Brew,2 Gregg B. Fields1 1 Department of Chemistry …
Family 6 Glycosyltransferases in Vertebrates and Bacteria: Inactivation and Horizontal Gene Transfer May Enhance Mutualism between Vertebrates and Bacteria
Type: Text
Year: 2010, 2010
Member of: FAU College Collections
Contributors: Acharya, K. Ravi, Brew, Keith, Tumbale, Percy
Full Text: JBC Papers in Press. Published on September 24, 2010 as Manuscript R110.176248 The latest version is at http://www.jbc.org/cgi/doi/10.1074/jbc.R110.176248 Family 6 Glycosyltransferases in Vertebrates and Bacteria: Inactivation and Horizontal Gene Transfer …
Engineered Sarafotoxins as Tissue Inhibitor of Metalloproteinases-like Matrix Metalloproteinase Inhibitors
Type: Text
Year: 2007, 2007
Member of: FAU College Collections
Contributors: Brew, Keith, Cudic, Mare, Fields, Gregg B., Lauer-Fields, Janelle L., Mari, Frank, Wei, Shuo
Full Text: THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 282, NO. 37, pp. 26948 –26955, September 14, 2007 © 2007 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in the U.S.A. Engineered Sarafotoxins as Tissue Inhibitor of …