FAU College Collections
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The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan
Type: Text
Year: 2017, 2017
Member of: FAU College Collections
Contributors: Jiuli Zhang, Justin Minnerly, Kailiang Jia, Thomas Parker, Tiffany Kaul
Publisher: Public Library of Science
Description: Restriction of dietary food without malnutrition robustly extends lifespan in more than
twenty species. It was also reported that fruit flies (Drosophila melanogaster) deficient in
olfactory function live longer and that the longevity induced by food restriction is partially
due to decreased olfaction. These observations suggest food assimilation through the gastrointestinal
tract and food… more
Full Text: RESEARCH ARTICLE The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan Justin Minnerly, Jiuli Zhang, Thomas Parker, Tiffany Kaul, Kailiang Jia* Department of Biological Sciences, Florida …
Intestinal autophagy activity is essential for host defense against Salmonella typhimurium infection in Caenorhabditis elega
Type: Text
Year: 2014, 2014
Member of: FAU College Collections
Contributors: Alexander Curt, Jiuli Zhang, Justin Minnerly, Kailiang Jia
Publisher: Elsevier
Description: Salmonella typhimurium infects both intestinal epithelial cells and macrophages. Autophagy is a lysosomal
degradation pathway that is present in all eukaryotes. Autophagy has been reported to limit the
Salmonella replication in Caenorhabditis elegans and in mammals. However, it is unknown whether intestinal
autophagy activity plays a role in host defense against Salmonella infection in C.… more
Full Text: Developmental and Comparative Immunology 45 (2014) 214–218 Contents lists available at ScienceDirect Developmental and Comparative Immunology journal homepage: www.elsevier.com/locate/dci Short communication Intestinal autophagy activity is essential for …
Guidelines for monitoring autophagy in Caenorhabditis elegans
Type: Text
Year: 2015, 2015
Member of: FAU College Collections
Contributors: Alicia Meléndez, Attila L Kovács, Bin Guo, Caroline Kumsta, Eyleen J O'Rourke, Fan Wu, Hong Zhang, Jessica T Chang, Kailiang Jia, Ken Sato, Long Lin, Louis R Lapierre, Malene Hansen, Miyuki Sato, Qun Lu, Renaud Legouis, Xiaochen Wang
Publisher: Taylor and Francis
Description: The cellular recycling process of autophagy has been extensively characterized with standard assays in yeast and
mammalian cell lines. In multicellular organisms, numerous external and internal factors differentially affect autophagy
activity in specific cell types throughout the stages of organismal ontogeny, adding complexity to the analysis of
autophagy in these metazoans. Here we summarize… more
Full Text: Autophagy ISSN: 1554-8627 (Print) 1554-8635 (Online) Journal homepage: http://www.tandfonline.com/loi/kaup20 Guidelines for monitoring autophagy in Caenorhabditis elegans Hong Zhang, Jessica T Chang, Bin Guo, Malene Hansen, Kailiang Jia, Attila L Kovács, …
egl‑4 modulates electroconvulsive seizure duration in C. elegans
Type: Text
Year: 2018, 2018
Member of: FAU College Collections
Contributors: Justin Minnerly, Kailiang Jia, Ken Dawson‑Scully, Monica G. Risley, Stephanie P. Kelly
Publisher: Springer Nature
Description: Increased neuronal excitability causes seizures with debilitating symptoms. Effective and noninvasive treatments are limited
for easing symptoms, partially due to the complexity of the disorder and lack of knowledge of specific molecular faults. An
unexplored, novel target for seizure therapeutics is the cGMP/protein kinase G (PKG) pathway, which targets downstream
K+
channels, a mechanism… more
Full Text: Invertebrate Neuroscience (2018) 18:8 https://doi.org/10.1007/s10158-018-0211-9 ORIGINAL ARTICLE egl‑4 modulates electroconvulsive seizure duration in C. elegans Monica G. Risley1,2 · Stephanie P. Kelly1,2 · Justin Minnerly1,2 · Kailiang Jia1,2 · Ken …
Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficien
Type: Text
Year: 2014, 2014
Member of: FAU College Collections
Contributors: Christopher E. Carr, Daniel J. Klionsky, Jennifer L. Johnson, Jie Qi, Kailiang Jia, Matthew Gill, Patrick Kobler, Peter E. Bayliss, Sergio D. Catz, Shanshan Lian, Sujay Guha, Tomoyuki Sasaki
Publisher: Public Library of Science
Description: Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H+-carbohydrate
transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces aberrant autolysosome formation that leads to embryonic senescence and accelerated aging symptoms, but little is known about the mechanisms leading to the pathogenesis in vivo. Beclin 1 and p53… more
Full Text: Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency Tomoyuki Sasaki1, Shanshan Lian1, Jie Qi1¤, Peter E. Bayliss2, Christopher E. Carr3, Jennifer L. …
A Protocol to Infect Caenorhabditis elegans with Salmonella typhimuri
Type: Text
Year: 2014, 2014
Member of: FAU College Collections
Contributors: Jiuli Zhang, Kailiang Jia
Publisher: MyJove Corporation
Description: In the last decade, C. elegans has emerged as an invertebrate organism to study interactions between hosts and pathogens, including the host defense against gram-negative bacterium Salmonella typhimurium. Salmonella establishes persistent infection in the intestine of C. elegans and results in early death of infected animals. A number of immunity mechanisms have been identified in C. elegans to… more
Full Text: Journal of Visualized Experiments www.jove.com Video Article A Protocol to Infect Caenorhabditis elegans with Salmonella typhimurium 1 1 Jiuli Zhang , Kailiang Jia 1 Department of Biological Sciences, Florida Atlantic University Correspondence to: …
Modulating Behavior in C. elegans Using Electroshock and Antiepileptic Drugs
Type: Text
Year: 2016, 2016
Member of: FAU College Collections
Contributors: Brock Grill, Kailiang Jia, Ken Dawson- Scully, Monica G. Risley, Stephanie P. Kelly
Publisher: PLoS ONE
Description: The microscopic nematode Caenorhabditis elegans has emerged as a valuable model for understanding the molecular and cellular basis of neurological disorders. The worm offers important physiological similarities to mammalian models such as conserved neuron morphology, ion channels, and neurotransmitters. While a wide-array of behavioral assays are available in C. elegans, an assay for electroshock… more
Full Text: RESEARCH ARTICLE Modulating Behavior in C. elegans Using Electroshock and Antiepileptic Drugs Monica G. Risley1☯, Stephanie P. Kelly1☯, Kailiang Jia1, Brock Grill2, Ken DawsonScully1* 1 Department of Biological Sciences, Florida Atlantic University, Boca …