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The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration

Type: Text

Year: 2016, 2016

Member of: FAU College Collections

Contributors: Borgen, Melissa A., Grill, Brock, Murphey, Rodney K.

Description: During development, a coordinated and integrated series of events must be accomplished in order to generate functional neural circuits. Axons must navigate toward target cells, build synaptic connections, and terminate outgrowth. The PHR proteins (consisting of mammalian Phr1/MYCBP2, Drosophila Highwire and C. elegans RPM-1) function in each of these events in development. Here, we review PHR… more

Full Text: Grill et al. Neural Development (2016) 11:8 DOI 10.1186/s13064-016-0063-0 REVIEW Open Access The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration Brock Grill1*, Rodney K. Murphey2 and Melissa A. Borgen1 Abstract …