FAU College Collections
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Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics
Type: Text
Year: 2002, 2002
Member of: FAU College Collections
Contributors: Brew, Keith, Nagase, Hideaki
Description: Matrix metalloproteinases (MMPs) play a central role in many biological processes such as development, morphogenesis and wound healing, but their unbalanced activities are implicated innumerous disease processes such as arthritis, cancer metastasis, atherosclerosis, nephritis and fibrosis. One of the key mechanisms to control MMP activities is inhibition by endogenous inhibitors called tissue… more
Full Text: Available online http://arthritis-research.com/content/4/S3/S051 Supplement Review Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics Hideaki Nagase* and Keith Brew† *The Kennedy Institute of Rheumatology Division, …
The Roles of Substrate Thermal Stability and P2 and P1′ Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity
Type: Text
Year: 2006, 2006
Member of: FAU College Collections
Contributors: Brew, Keith, Cudic, Mare, Fields, Gregg B., Lauer-Fields, Janelle L., Minond, Dmitriy, Nagase, Hideaki, Overall, Christopher M., Pei, Duanqing, Visse, Robert
Full Text: THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 281, NO. 50, pp. 38302–38313, December 15, 2006 © 2006 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in the U.S.A. The Roles of Substrate Thermal Stability and P2 and P1ⴕ Subsite …
Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications
Type: Text
Year: 2010, 2010
Member of: FAU College Collections
Contributors: Brew, Keith, Enghild, Jan J., Jones, Jonathan, Kashiwagi, Masahide, Lim, Ngee H., Nagase, Hideaki, Visse, Robert
Full Text: www.biochemj.org Biochem. J. (2010) 431, 113–122 (Printed in Great Britain) 113 doi:10.1042/BJ20100725 Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications Ngee H. LIM*, Masahide …