FAU College Collections
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Gold Nanoparticles as a Probe for Amyloid-β Oligomer and Amyloid Formation
Type: Text
Year: 2017, 2017
Member of: FAU College Collections
Contributors: Bimlesh Ojha, Clifford Morris, Deguo Du, Esmail A. Elbassal, Ewa P. Wojcikiewicz, Thomas W. Kent
Description: The process of amyloid-β (Aβ) amyloid formation is pathologically linked to Alzheimer’s disease
(AD). The identification of Aβ amyloids and intermediates that are crucial players in the
pathology of AD is critical for exploring the underlying mechanism of Aβ aggregation and the
diagnosis of the disease. Herein, we performed a gold nanoparticle (AuNP)-based study to detect
the formation of Aβ… more
Full Text: HHS Public Access Author manuscript Author Manuscript J Phys Chem C Nanomater Interfaces. Author manuscript; available in PMC 2017 December 20. Published in final edited form as: J Phys Chem C Nanomater Interfaces. 2017 September 14; 121(36): 20007–20015. …
A Kinetic Aggregation Assay Enabling Selective and Sensitive Aβ Amyloid Quantification in Cells and Tissues
Type: Text
Year: 2011, 2011
Member of: FAU College Collections
Contributors: Amber N. Murray, Andrew Dillin, Deguo Du, Ehud Cohen, Hyun-Eui Kim, Jeffery W. Kelly, Ryan Simkovsky
Description: The process of amyloid-β (Aβ) fibril formation is genetically and pathologically linked to
Alzheimer's disease (AD). Thus, a selective and sensitive method for the quantification of Aβ
amyloid fibrils in complex biological samples enables a variety of hypotheses to be tested. Herein
we report the basis for a quantitative in vitro kinetic aggregation assay that detects seeding competent… more
Full Text: NIH Public Access Author Manuscript Biochemistry. Author manuscript; available in PMC 2012 March 15. NIH-PA Author Manuscript Published in final edited form as: Biochemistry. 2011 March 15; 50(10): 1607–1617. doi:10.1021/bi1013744. A Kinetic Aggregation …