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Differential Effects of Human L1CAM Mutations on Complementing Guidance and Synaptic Defects in Drosophila melanogaster
Type: Text
Year: 2013, 2013
Member of: FAU College Collections
Contributors: Freund, Julie, Godenschwege, Tanja A., Hortsch, Michael, Kudumala, Sirisha, Labrador, Juan-Pablo
Description: A large number of different pathological L1CAM mutations have been identified that result in a broad spectrum of
neurological and non-neurological phenotypes. While many of these mutations have been characterized for their effects on
homophilic and heterophilic interactions, as well as expression levels in vitro, there are only few studies on their biological
consequences in vivo. The single… more
Full Text: Differential Effects of Human L1CAM Mutations on Complementing Guidance and Synaptic Defects in Drosophila melanogaster Sirisha Kudumala1, Julie Freund1, Michael Hortsch2, Tanja A. Godenschwege1* 1 Department of Biological Sciences, Florida Atlantic …