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A Kinetic Aggregation Assay Enabling Selective and Sensitive Aβ Amyloid Quantification in Cells and Tissues
Type: Text
Year: 2011, 2011
Member of: FAU College Collections
Contributors: Amber N. Murray, Andrew Dillin, Deguo Du, Ehud Cohen, Hyun-Eui Kim, Jeffery W. Kelly, Ryan Simkovsky
Description: The process of amyloid-β (Aβ) fibril formation is genetically and pathologically linked to
Alzheimer's disease (AD). Thus, a selective and sensitive method for the quantification of Aβ
amyloid fibrils in complex biological samples enables a variety of hypotheses to be tested. Herein
we report the basis for a quantitative in vitro kinetic aggregation assay that detects seeding competent… more
Full Text: NIH Public Access Author Manuscript Biochemistry. Author manuscript; available in PMC 2012 March 15. NIH-PA Author Manuscript Published in final edited form as: Biochemistry. 2011 March 15; 50(10): 1607–1617. doi:10.1021/bi1013744. A Kinetic Aggregation …