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Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity

Type: Text

Year: 2016, 2016

Member of: FAU College Collections

Contributors: Amar, Sabrina, Cerofolini, Linda, Fields, Gregg B., Fragai, Marco, Lauer, Janelle L., Luchinat, Claudio, Martelli, Tommaso

Description: Cell surface proteolysis is an integral yet poorly understood physiological process. The present study has examined how the pericellular collagenase membrane-type 1 matrix metalloproteinase (MT1-MMP) and membrane-mimicking environments interplay in substrate binding and processing. NMR derived structural models indicate that MT1-MMP transiently associates with bicelles and cells through… more

Full Text: www.nature.com/scientificreports OPEN received: 05 August 2015 accepted: 20 June 2016 Published: 13 July 2016 Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity Linda Cerofolini1, Sabrina …