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New Tools for Targeted Disruption of Cholinergic Synaptic Transmission in Drosophila melanogaster

Type: Text

Year: 2013, 2013

Member of: FAU College Collections

Contributors: Godenschwege, Tanja A., Heghinian, Mari D., Mari, Frank, McCabe, Brian D., Mejia, Monica

Description: Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels. The a7 subtype of nAChRs is involved in neurological pathologies such as Parkinson’s disease, Alzheimer’s disease, addiction, epilepsy and autism spectrum disorders. The Drosophila melanogaster a7 (Da7) has the closest sequence homology to the vertebrate a7 subunit and it can form homopentameric receptors just… more

Full Text: New Tools for Targeted Disruption of Cholinergic Synaptic Transmission in Drosophila melanogaster Monica Mejia1, Mari D. Heghinian2, Frank Marı́2, Tanja A. Godenschwege3* 1 Department of Biological Sciences, Florida Atlantic University, Boca Raton, …