FAU College Collections
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Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics
Type: Text
Year: 2002, 2002
Member of: FAU College Collections
Contributors: Brew, Keith, Nagase, Hideaki
Description: Matrix metalloproteinases (MMPs) play a central role in many biological processes such as development, morphogenesis and wound healing, but their unbalanced activities are implicated innumerous disease processes such as arthritis, cancer metastasis, atherosclerosis, nephritis and fibrosis. One of the key mechanisms to control MMP activities is inhibition by endogenous inhibitors called tissue… more
Full Text: Available online http://arthritis-research.com/content/4/S3/S051 Supplement Review Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics Hideaki Nagase* and Keith Brew† *The Kennedy Institute of Rheumatology Division, …