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Fedora URI https://fcrepo-fau.isle.flvc.org/fcrepo/rest/6a/e4/3c/20/6ae43c20-ebe8-4fc2-9c3f-da014875808d

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Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficien

Type: Text

Year: 2014, 2014

Member of: FAU College Collections

Contributors: Christopher E. Carr, Daniel J. Klionsky, Jennifer L. Johnson, Jie Qi, Kailiang Jia, Matthew Gill, Patrick Kobler, Peter E. Bayliss, Sergio D. Catz, Shanshan Lian, Sujay Guha, Tomoyuki Sasaki

Publisher: Public Library of Science

Description: Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H+-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces aberrant autolysosome formation that leads to embryonic senescence and accelerated aging symptoms, but little is known about the mechanisms leading to the pathogenesis in vivo. Beclin 1 and p53… more

Full Text: Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency Tomoyuki Sasaki1, Shanshan Lian1, Jie Qi1¤, Peter E. Bayliss2, Christopher E. Carr3, Jennifer L. …