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The Drosophila Mitochondrial Translation Elongation Factor G1 Contains a Nuclear Localization Signal and Inhibits Growth and DPP Signaling
Type: Text
Year: 2011, 2011
Member of: FAU College Collections
Contributors: Haerry, Theodor E., Treisman, Jessica, Trivigno, Catherine F.
Description: Mutations in the human mitochondrial elongation factor G1 (EF-G1) are recessive lethal and cause death shortly after birth.
We have isolated mutations in iconoclast (ico), which encodes the highly conserved Drosophila orthologue of EF-G1. We find
that EF-G1 is essential during fly development, but its function is not required in every tissue. In contrast to null mutations,
missense mutations… more
Full Text: The Drosophila Mitochondrial Translation Elongation Factor G1 Contains a Nuclear Localization Signal and Inhibits Growth and DPP Signaling Catherine Trivigno1,2¤, Theodor E. Haerry1* 1 Center for Molecular Biology and Biotechnology, Florida Atlantic …