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The Lack of CuZnSOD Leads to Impaired Neurotransmitter Release, Neuromuscular Junction Destabilization and Reduced Muscle Strength in Mice
Type: Text
Year: 2014, 2014
Member of: FAU College Collections
Contributors: Ivannikov, Maxim V., Jaramillo, Carlos A., Liu, Yuhong, Macleod, Gregory, Phillips, William, Shi, Yun, Van Remmen, Holly, Walsh, Michael E., Zhang, Yiqiang
Description: Elevated reactive oxygen species (ROS) production and ROS-dependent protein damage is a common observation in the
pathogenesis of many muscle wasting disorders, including sarcopenia. However, the contribution of elevated ROS levels to
–a breakdown in neuromuscular communication and muscle atrophy remains unknown. In this study, we examined a
copper zinc superoxide dismutase [CuZnSOD (Sod1)]… more
Full Text: The Lack of CuZnSOD Leads to Impaired Neurotransmitter Release, Neuromuscular Junction Destabilization and Reduced Muscle Strength in Mice Yun Shi1,2,3., Maxim V. Ivannikov1,4., Michael E. Walsh1,2, Yuhong Liu1,2,3, Yiqiang Zhang1,4, Carlos A. …