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Emergence of epilepsy in a transgenic mouse strain that over-expressesbrain- derived neurotrophic factor in theforebrain

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Type: Text
Year: 2016, 2016, 2016, 2016
Member of: FAU Undergraduate Student Research
Contributors: Isgor, Ceylan, Zhou, Wei Hui
Publisher: Florida Atlantic University
Description: Structural changes that alter hippocampal functional circuitry are implicated in learning impairments, mood disorders and epilepsy. Failure to properly gate neuronal activity arriving in hippocampus may be critical in developing synaptic circuits that generate seizures due to sustained elevations in hippocampal BDNF. Our data shows higher number of synaptic contact points (spines) on… more
Full Text: Emergence of epilepsy in a transgenic mouse strain that over-expresses brainderived neurotrophic factor in the forebrain Wei Hui Zhou, Mary Laquerre, Ceylan Isgor Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic …

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