FAU Undergraduate Student Research
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Development and Optimization of AlphaScreen Assay for Discovery of Galectin-1/-3 Inhibitors
Type: Text
Year: 2018, 2018, 2018, 2018
Member of: FAU Undergraduate Student Research
Contributors: Cudic, Mare, Fitzgerald, Forrest, Rivero, Yaima
Publisher: Florida Atlantic University
Description: Galectin-1 is a beta-galactoside-binding protein implicated in regulating apoptosis, cell proliferation and cell differentiation. The objective of our research was to develop and optimize an assay format for the discovery of new inhibitors of galectin-1 using AlphaScreen technology in a competitive binding configuration. Our efforts were hampered by the weak binding affinities of galectin-1 for… more
Full Text: Development and Optimization of AlphaScreen Assay for Discovery of Galectin-1/-3 Inhibitors. Yaima Rivero, Forrest FitzGerald, and Mare Cudic, Ph. D. HYPOTHESIS An assay format for the discovery of new inhibitors of galectin-1/-3 (Gal-1/-3) using the …