FAU Undergraduate Student Research
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Synthesis of Podophyllotoxin Derivatives
Type: Text
Year: 2014, 2014
Member of: FAU Undergraduate Student Research
Contributors: Flint, Madison, Roche, Stephane P.
Publisher: Florida Atlantic University Digital Library
Description: Podophyllotoxin is a natural aryltetralin lignan compound isolated from plants within the genus Podophyllum. Podophyllotoxin has been under extensive biochemical investigation since the discovery of its biological activity as a strong microtubule destabilizing mitotic agent. Although these antineoplastic compounds have shown significant activity as cancerous cell growth inhibitors, they lack… more
Full Text: … Florida Atlantic University Digital Library …
Synthesis of Complex Polycyclic Scaffolds Incorporating α-Amino Esters
Type: Text
Year: 2015, 2015
Member of: FAU Undergraduate Student Research
Contributors: Roche, Stephane P., Samanta, Shyam S., Zorc, Stephen A.
Publisher: Florida Atlantic University Libraries: Digital Library
Description: In order to keep up with the high demand for
biologically active molecules, chemists devised
several synthetic strategies to access novel chemical
spaces. The two main strategies to construct new
scaffolds are to revisit underexploited or forgotten
reactions or to devise new transformations. We are
exploring a unique and underexploited reaction, the
Himbert–Henn cycloaddition, to produce… more
Full Text: … Florida Atlantic University Libraries: Digital Library …
2-Hydroxychalcone as a Unique Luminescent Probe (ESIPT) for Peptides Labeling
Type: Text
Year: 2016, 2016, 2016, 2016
Member of: FAU Undergraduate Student Research
Contributors: Kempton, Thomas G., Roche, Stephane P., Samanta, Shyam S.
Publisher: Florida Atlantic University
Description: Peptides and proteins with photochemical sensors
are valuable tools when analyzing biochemical processes
and peptide properties. Recent work on
fluorescent α-amino acids (FlAAs) proved extremely
useful in studying protein folding, conformational
changes and reactivity. When fluorescent tags are
appropriately attached to proteins they allow for the
detection of their environment and changes… more
Full Text: 2-Hydroxychalcone as a Unique Luminescent Probe (ESIPT) for Peptides Labeling Thomas G. Kempton, Shyam S. Samanta, Dr. Stéphane P. Roche Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science, Florida Atlantic University i. UV-Vis …