Florida Atlantic University Patents
Displaying 1 - 2 of 2
Neuroprotection from Brain Anoxia and Reperfusion Injury During Stroke and Compositions of PKG Pathway Activators and Method of Use Thereof, 2011
Type: Text
Year: 2011, 2011, 2011, 2011
Member of: Florida Atlantic University Patents
Contributors: Dawson-Scully, Ken, Milton, Sara Louise
Publisher: Florida Atlantic University
Description: A pharmaceutical composition for treating or preventing one
or both of neural anoxia and reperfusion injury, which
includes a pharmacological activator of the PKG pathway,
and methods of treating or preventing medical conditions
using a pharmacological activator of the PKG pathway.
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Compositions and Methods for Treating Neural Anoxia and Spreading Depression, 2011
Type: Text
Year: 2011, 2011, 2011, 2011
Member of: Florida Atlantic University Patents
Contributors: Dawson-Scully, Ken, Robertson, R. Meldrum
Publisher: Florida Atlantic University
Description: Compositions and methods for protecting neural tissue (e.g.,
neurons) from anoxia and spreading depression (SD) involve
inhibiting the cGMP-dependent protein kinase (PKG) pathway.
It was discovered that the PKG pathway plays a crucial
role in regulating SD and tolerance to anoxia in the central
nervous system (CNS). Inhibition of the PKG pathway
greatly reduces SD and increases tolerance to… more
Full Text: … Florida Atlantic University …