Hamacanthins A and B. New antifungal bis indole alkaloids from the deep-water marine sponge, Hamacantha sp

Hamacanthin A [1] and hamacanthin B [2] are two bioactive dihydropyrazinonediylbis(indole) alkaloids isolated from a new species of deep-water marine sponge, Hamacantha sp. The hamacanthins are growth inhibitors of Candida albicans and Cryptococcus neoformans. Isolation and structure elucidation of 1 and 2 by nmr spectroscopy are described.

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50112a014. This article may be cited as: Gunasekera, S. P., McCarthy, P. J., & Kelly-Borges, M. (1994). Hamacanthins A and B. New antifungal bis indole alkaloids from the deep-water marine sponge, Hamacantha sp. Journal of Natural Products, 57(10), 1437-1441. doi:10.1021/np50112a014

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1045.