Note
In our efforts to begin to determine the exact mechanism of action by which discodermolide suppresses immune responsiveness, we discovered that the compound exerted antiproliferative activity toward a number of cell lines of different tissue types and origin. In the present article, we will summarize the work to date regarding discodermolide's immunosuppressive activity and we will describe the compound's ability to block proliferation in lymphoid and nonlymphoid cells and correlate the effect with changes we have observed in cell cycling patterns observed in T hybridoma cells treated with the compound.