Two immunosuppressive compounds, 4 α-methyl-5 α-cholest-8-en-3 β-ol and 4, 5-dibromo-2-pyrrolic acid [2] were isolated from a deep water marine sponge, Agelas flabelliformis. Their structures were determined by comparison of their spectral data with those of samples isolated from other organisms. Both compounds were highly active in suppression of the response of murine splenocytes in the two-way mixed lymphocyte reaction (MLR) with little to no demonstrable cytotoxicity at lower doses. In addition, 4, 5-dibromo-2-pyrrolic acid suppressed the proliferative response of splenocytes to suboptimal concentrations of the mitogen, concanavalin A (Con A). These results describe for the first time compounds isolated from the marine sponge A. flabelliformis that possess potent in vitro immunosuppressive activity.
Member of
Contributors
Publisher
The American Chemical Society and American Society of Pharmacognosy
Date Issued
1989
Note
Language
Type
Genre
Extent
6 p.
Subject (Topical)
Identifier
3332960
Additional Information
Two immunosuppressive compounds, 4 α-methyl-5 α-cholest-8-en-3 β-ol and 4, 5-dibromo-2-pyrrolic acid [2] were isolated from a deep water marine sponge, Agelas flabelliformis. Their structures were determined by comparison of their spectral data with those of samples isolated from other organisms. Both compounds were highly active in suppression of the response of murine splenocytes in the two-way mixed lymphocyte reaction (MLR) with little to no demonstrable cytotoxicity at lower doses. In addition, 4, 5-dibromo-2-pyrrolic acid suppressed the proliferative response of splenocytes to suboptimal concentrations of the mitogen, concanavalin A (Con A). These results describe for the first time compounds isolated from the marine sponge A. flabelliformis that possess potent in vitro immunosuppressive activity.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np50064a015. This article may be cited as: Gunasekera, S. P., Cranick, S., & Longley, R. E. (1989). Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis. Journal of Natural Products, 52(4) 757-761. doi:10.1021/np50064a015
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #710.
Date Backup
1989
Date Text
1989
DOI
10.1021/np50064a015
Date Issued (EDTF)
1989
Extension
FAU
FAU
admin_unit="FAU01", ingest_id="ing12079", creator="creator:BCHANG", creation_date="2012-02-22 07:48:58", modified_by="super:FAUDIG", modification_date="2014-02-13 10:32:33"
IID
FADT3332960
Issuance
single unit
Organizations
Attributed name: Harbor Branch Oceanographic Institute
Person Preferred Name
Gunasekera, Sarath P.
creator
Physical Description
6 p.
Title Plain
Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis
Origin Information
The American Chemical Society and American Society of Pharmacognosy
1989
single unit
Title
Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis
Other Title Info
Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis