Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2017
EDTF Date Created
2017
Description
While natural products have served as a prolific
source of unique chemistry, supply remains a significant
obstacle for drug discovery. The overall goal
of this project is to determine whether isolation and
semi-synthesis can provide adequate quantities for
biological evaluation. Erythropodium caribaeorum is
an abundant gorgonian in the Caribbean that produces
two unique marine diterpenoids, erythrolides
A and B, which have been shown to undergo photochemical
transformations to yield more complex
chemistry. In this project, erythrolides A and B will be
isolated from E. caribaeorum collected off the coast
of Boca Raton, Florida. These compounds will be
exposed to ultraviolet light and analyzed to identify
any chemical changes. New compounds will then
be subjected to biological screening for cytotoxicity
against human cancer cell lines. This project will
not only identify new bioactive compounds but also
provide a novel route for the large-scale production
of medically relevant marine natural products.
source of unique chemistry, supply remains a significant
obstacle for drug discovery. The overall goal
of this project is to determine whether isolation and
semi-synthesis can provide adequate quantities for
biological evaluation. Erythropodium caribaeorum is
an abundant gorgonian in the Caribbean that produces
two unique marine diterpenoids, erythrolides
A and B, which have been shown to undergo photochemical
transformations to yield more complex
chemistry. In this project, erythrolides A and B will be
isolated from E. caribaeorum collected off the coast
of Boca Raton, Florida. These compounds will be
exposed to ultraviolet light and analyzed to identify
any chemical changes. New compounds will then
be subjected to biological screening for cytotoxicity
against human cancer cell lines. This project will
not only identify new bioactive compounds but also
provide a novel route for the large-scale production
of medically relevant marine natural products.
Language
Type
Genre
Form
Extent
1 p.
Subject (Topical)
Identifier
FA00005640
Date Backup
2017
Date Created Backup
2017
Date Text
2017
Date Created (EDTF)
2017
Date Issued (EDTF)
2017
Extension
FAU
IID
FA00005640
Organizations
Attributed name: Office of Undergraduate Research and Inquiry
Person Preferred Name
Williams, Shakia
Physical Description
application/pdf
1 p.
Title Plain
Isolation and Biomimetic Synthesis of Marine Natural Products
Origin Information
2017
2017
Florida Atlantic University
Boca Raton, Florida
Physical Location
Florida Atlantic University Libraries
Place
Boca Raton, Florida
Sub Location
Digital Library
Title
Isolation and Biomimetic Synthesis of Marine Natural Products
Other Title Info
Isolation and Biomimetic Synthesis of Marine Natural Products