Leiodermatolide is a structurally unique macrolide isolated from the deep-water marine sponge Leiodermatium sp. which exhibits potent antiproliferative activity against a range of human cancer cell lines and drastic effects on spindle formation in mitotic cells. Its unprecedented polyketide skeleton and stereochemistry were established using a combination of experimental and computational NMR methods.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution 1825
This manuscript is an author version with the final publication available at
http://onlinelibrary.wiley.com/ and may be cited as: Paterson, I., Dalby, S. M., Roberts, J. C., Naylor,
G. J., Guzmán, E. A., Isbrucker, R., Pitts, T. P., Linley, P., Divlianska, D., Reed, J. K., & Wright, A. E.
(2011). Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.
Angewandte Chemie International Edition, 50(14), 3219-3223. doi: 10.1002/anie.201007719