Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp.

Member of
HBOI Faculty Contributions
Contributors
Carney, J. R.
Scheuer, P. J.
Kelly-Borges, M.
Publisher
Elsevier B.V.
Date Issued
1993
Note

A cytotoxic pigment, makaluvamine G (5), biogenetically derivable from tryptamine and tyramine and structurally related to the discorhabdins, was isolated from a sponge of the genus Histodermella collected in Indonesia. The compound displays significant in vitro cytotoxicity to several tumor cell lines and is a moderate inhibitor of topoisomerase-I, DNA, RNA, and protein synthesis. Makaluvamine G (5) was isolated from the sponge Histodermella sp. The compound shows significant in vitro cytotoxicity to several human tumor cell lines and inhibits topoisomerase-I (IC50 = 3 μM), RNA (15 μM), DNA (15 μM) and protein (21 μM) synthesis

Language
English
Type
Text
Genre
article
Extent
5 p.
Subject (Topical)
Sponges
Cytotoxin
Tryptamine--Derivatives--Synthesis
Tyramine
Antineoplastic agents
Identifier
3331874
Additional Information
A cytotoxic pigment, makaluvamine G (5), biogenetically derivable from tryptamine and tyramine and structurally related to the discorhabdins, was isolated from a sponge of the genus Histodermella collected in Indonesia. The compound displays significant in vitro cytotoxicity to several tumor cell lines and is a moderate inhibitor of topoisomerase-I, DNA, RNA, and protein synthesis. Makaluvamine G (5) was isolated from the sponge Histodermella sp. The compound shows significant in vitro cytotoxicity to several human tumor cell lines and inhibits topoisomerase-I (IC50 = 3 μM), RNA (15 μM), DNA (15 μM) and protein (21 μM) synthesis
This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/00404020 and may be cited as: Carney, J. R., Scheuer, P. J., & Kelly-Borges, M. (1993). Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp. Tetrahedron, 49(38), 8483-8486. doi:10.1016/S0040-4020(01)96256-8
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #976.
Date Backup
1993
Date Text
1993
DOI
10.1016/S0040-4020(01)96256-8
Date Issued (EDTF)
1993
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing11825", creator="creator:BCHANG", creation_date="2012-01-12 08:02:44", modified_by="super:FAUDIG", modification_date="2014-02-13 08:23:40"

IID
FADT3331874
Issuance
single unit
Organizations
Attributed name: Harbor Branch Oceanographic Institute
Person Preferred Name

Carney, J. R.

creator

Physical Description

pdf
5 p.
PURL
http://purl.flvc.org/FCLA/DT/3331874
Title Plain
Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp.
URL
http://purl.flvc.org/FCLA/DT/3331874
Origin Information

Elsevier B.V.
1993
single unit
Title
Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp.
Other Title Info

Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp.