Note
Includes bibliography.
Member of
Contributors
Publisher
Florida Atlantic University Digital Library
Date Issued
2011
EDTF Date Created
2011
Description
Ghrelin is a 28-amino acid peptide secreted by the stomach. Over the past decade,
studies have shown ghrelin to have broad effects on growth hormone release, appetite
regulation, and glucose metabolism. These effects are explained largely by the high
expression of the ghrelin receptor (GHS-R1a) in both the hypothalamus and pituitary.
Recently, ghrelin has been shown to have possible neuroprotective effects in other brain
regions expressing GHS-R1a, specifically stimulating anti-apoptotic and antiinflammatory
pathways. The endoplasmic reticulum (ER) is a cellular organelle
responsible for processing proteins. When an abundance of misfolded proteins
accumulate in the ER, cellular stress pathways ensue, and are linked to a number of
neurodegenerative diseases. This project will examine the effects of ghrelin during ER
stress in a human neuronal cell line. Expression of genes and proteins involved in
potential neuroprotective pathways will be examined to learn how ghrelin mediates its
anti-apoptotic effects in neurons.
studies have shown ghrelin to have broad effects on growth hormone release, appetite
regulation, and glucose metabolism. These effects are explained largely by the high
expression of the ghrelin receptor (GHS-R1a) in both the hypothalamus and pituitary.
Recently, ghrelin has been shown to have possible neuroprotective effects in other brain
regions expressing GHS-R1a, specifically stimulating anti-apoptotic and antiinflammatory
pathways. The endoplasmic reticulum (ER) is a cellular organelle
responsible for processing proteins. When an abundance of misfolded proteins
accumulate in the ER, cellular stress pathways ensue, and are linked to a number of
neurodegenerative diseases. This project will examine the effects of ghrelin during ER
stress in a human neuronal cell line. Expression of genes and proteins involved in
potential neuroprotective pathways will be examined to learn how ghrelin mediates its
anti-apoptotic effects in neurons.
Language
Type
Genre
Form
Extent
61 p.
Identifier
FA00003595
Rights
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Additional Information
Includes bibliography.
Thesis (B.A.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2011.
Date Backup
2011
Date Created Backup
2011
Date Text
2011
Date Created (EDTF)
2011
Date Issued (EDTF)
2011
Extension
FAU
IID
FA00003595
Organizations
Attributed name: Harriet L. Wilkes Honors College
Attributed name: Florida Atlantic University
Person Preferred Name
Metzner, Michael John
author
Harriet L. Wilkes Honors College
Physical Description
online resource
61 p.
Title Plain
Mechanisms of Neuroprotection Mediated by Ghrelin in Neuronal Cells
Use and Reproduction
Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
2011
2011
Florida Atlantic University Digital Library
Boca Raton, Fla.
Place
Boca Raton, Fla.
Title
Mechanisms of Neuroprotection Mediated by Ghrelin in Neuronal Cells
Other Title Info
Mechanisms of Neuroprotection Mediated by Ghrelin in Neuronal Cells