Microxine, a New cdc2 Kinase Inhibitor from the Australian MarinE Sponge Microxina Species

A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC50 of 13 µM.

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np000546z. This article may be cited as: Killday, K. B., Yarwood, D., Sills, M. A., Murphy, P. T., Hooper, J. N. A., & Wright, A. E. (2001). Microxine, a New cdc2 Kinase Inhibitor from the Australian Marine Sponge Microxina Species. Journal of Natural Products, 64(4), 525-526.

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1400.