THE MOST EFFECTIVE TREATMENT FOR CANINE INTERVERTEBRAL DISC DISEASE

Intervertebral disc disease, or IVDD, involves damage to the discs between vertebrae in the
spinal column of vertebrates. The disease is progressive and has a significant genetic component
as well as influences from the patient’s lifestyle. This thesis examines IVDD in canines,
evaluating the cause, currently available and under research treatment options, and considers
future research into mitigating the severity of disease progression. Results suggest that with
current knowledge, a combination of surgical correction and conservative management yields the
best outcome for the patient, decreasing in effectiveness as the disease progresses. Novel
treatment options include cell-based, gene, and growth factor therapies that have greater potential
with severe cases. This paper suggests targeting the root of the problem to minimize the extent of
treatment needed. Educating breeders and pet owners to catch the early onset of the disease will
not only minimize detriment to the patient but also increase the number of cases seen by
veterinarians, which will allow a greater understanding of the disease’s mechanisms and
increased knowledge for laboratory work. The One Health concept allows the transfer of
knowledge of the disease between human and veterinary medicine, which should be pushed to
further expand the research of IVDD.