New Bioactive Peroxides from Marine Sponges of the Family Plakiniidae

Member of
HBOI Faculty Contributions
Contributors
Chen, Ying
McCarthy, Peter J.
Harmody, Dedra K.
Schimoler, Rebecca
Chilson, Katherine
Selitrennikoff, Claude
Pomponi, Shirley A.
Wright, Amy E.
Publisher
American Chemical Society and American Society of Pharmacognosy
Date Issued
2002
Note

In our continuing program to identify compounds with antifungal properties, the ethanol extracts of two sponges of the family Plakinidae were found to inhibit the growth of the fungal pathogens Candida albicans and Aspergillus fumigatus. From these organisms three new compounds and five known compounds have been identified. A new 1,2-dioxane ring peroxide acid, 1, has been isolated from the sponge Plakortis halichondrioides along with five known compounds. Two new 1,2-dioxolane peroxide acids, 3 and 4, have been isolated from the sponge Plakinastrella onkodes. The structures were established by interpretation of spectral data.

Language
English
Type
Text
Genre
article
Extent
5 p.
Subject (Topical)
Sponges
Peroxides
Pathogenic fungi
Candida albicans
Aspergillus fumigatus
Identifier
3164099
Additional Information
In our continuing program to identify compounds with antifungal properties, the ethanol extracts of two sponges of the family Plakinidae were found to inhibit the growth of the fungal pathogens Candida albicans and Aspergillus fumigatus. From these organisms three new compounds and five known compounds have been identified. A new 1,2-dioxane ring peroxide acid, 1, has been isolated from the sponge Plakortis halichondrioides along with five known compounds. Two new 1,2-dioxolane peroxide acids, 3 and 4, have been isolated from the sponge Plakinastrella onkodes. The structures were established by interpretation of spectral data.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np0200414. This article may be cited as: Chen, Y., McCarthy, P. J., Harmody, D. K., Schimoler-O’Rourke, R., Chilson, K., Selitrennikoff, C., Pomponi, S. A., & Wright, A. E. (2002). New Bioactive Peroxides from Marine Sponges of the Family Plakiniidae. Journal of Natural Products, 65(10), 1509-1512.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1478.
Date Backup
2002
Date Text
2002
DOI
10.1021/np0200414
Date Issued (EDTF)
2002
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing9351", creator="creator:BCHANG", creation_date="2011-04-25 13:46:25", modified_by="super:FAUDIG", modification_date="2014-02-10 14:20:16"

IID
FADT3164099
Issuance
single unit
Person Preferred Name

Chen, Ying

creator

Physical Description

pdf
5 p.
PURL
http://purl.flvc.org/FCLA/DT/3164099
Title Plain
New Bioactive Peroxides from Marine Sponges of the Family Plakiniidae
URL
http://purl.flvc.org/FCLA/DT/3164099
Origin Information

American Chemical Society and American Society of Pharmacognosy
2002
single unit
Title
New Bioactive Peroxides from Marine Sponges of the Family Plakiniidae
Other Title Info

New Bioactive Peroxides from Marine Sponges of the Family Plakiniidae