A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.

Member of
HBOI Faculty Contributions
Contributors
Yang, Shu-Wei
Chan, Tze-Ming
Pomponi, Shirley A.
Gonsiorek, W.
Chen, Guodong
Wright, Amy E.
Hipkin, W.
Patel, Mahesh
Gullo, Vincent
Pramanik, B.
Zavodny, P.
Chu, Min
Publisher
Nature Publishing Group
Date Issued
2003
Note

Marine organisms are an excellent source of structurally diverse molecules which are potentially useful for drug discovery. Several marine natural products have been discovered as lead compounds in various therapeutic areas, and some of them are currently in clinical studies. In our marine natural product research program, we have built a marine fraction library (MFL) for high throughput screening (HTS) for a variety of biological targets. The active fractions are followed up using bioassay-guided fractionation to identify the active compounds. Isolation and identification of CCR7 receptor binding inhibitors from the marine sponge lrcinia sp. are described in this paper.

Language
English
Type
Text
Genre
article
Extent
5 p.
Subject (Topical)
Sponges
Sesterterpenes
Marine natural products
Identifier
3351980
Additional Information
Marine organisms are an excellent source of structurally diverse molecules which are potentially useful for drug discovery. Several marine natural products have been discovered as lead compounds in various therapeutic areas, and some of them are currently in clinical studies. In our marine natural product research program, we have built a marine fraction library (MFL) for high throughput screening (HTS) for a variety of biological targets. The active fractions are followed up using bioassay-guided fractionation to identify the active compounds. Isolation and identification of CCR7 receptor binding inhibitors from the marine sponge lrcinia sp. are described in this paper.
This manuscript is an author version with the final publication available at http://www.nature.com/ja/index.html and may be cited as: Yang, S.-W., Chan, T.-M., Pomponi, S. A., Gonsiorek, W., Chen, G., Wright, A. E., Hipkin, W., Patel, M., Gullo, V., Pramanik, B., Zavodny, P., & Chu, M. (2003). A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp. The Journal of Antibiotics, 56(9), 783-786. doi:10.7164/antibiotics.56.783
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1540.
Date Backup
2003
Date Text
2003
DOI
10.7164/antibiotics.56.783
Date Issued (EDTF)
2003
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing13518", creator="creator:BCHANG", creation_date="2012-08-10 17:29:40", modified_by="super:FAUDIG", modification_date="2014-02-14 14:01:45"

IID
FADT3351980
Issuance
single unit
Person Preferred Name

Yang, Shu-Wei

creator

Physical Description

pdf
5 p.
PURL
http://purl.flvc.org/FCLA/DT/3351980
Title Plain
A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
URL
http://purl.flvc.org/FCLA/DT/3351980
Origin Information

Nature Publishing Group
2003
single unit
Title
A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
Other Title Info

A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.