A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis

Member of
HBOI Faculty Contributions
Contributors
Guzman, Esther A.
Johnson, J. D.
Linley, P. A.
Wright, Amy E.
Gunasekera, Sarath P.
Publisher
Springer Science+Business Media, LLC
Date Issued
2010
Note

The effects of Manzamine A were studied in pancreatic cancer cells. Methods: AsPC-1 cells were treated for 48 h in the presence of various concentrations of Manzamine A and their phenotype, cytotoxicity, cell invasion and susceptibility to apoptosis were observed. Manzamine A decreased single cell formation, abrogated cell migration and restored the susceptibility of the cells to TRAIL-induced apoptosis in AsPC-1 cells.

Language
English
Type
Text
Genre
article
Extent
10 p.
Subject (Topical)
Pancreas--Cancer
Apoptosis
Sponges--Research
Marine natural products
Drug Discovery
Identifier
3318907
Additional Information
The effects of Manzamine A were studied in pancreatic cancer cells. Methods: AsPC-1 cells were treated for 48 h in the presence of various concentrations of Manzamine A and their phenotype, cytotoxicity, cell invasion and susceptibility to apoptosis were observed. Manzamine A decreased single cell formation, abrogated cell migration and restored the susceptibility of the cells to TRAIL-induced apoptosis in AsPC-1 cells.
This manuscript is an author version with the final publication available at http://www.springerlink.com and may be cited as: Guzmán, E. A., Johnson, J. D., Linley, P. A., Gunasekera, S. E., & Wright, A. E. (2010). A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis. Investigational New Drugs, 29(5), 777-785. doi:10.1007/s10637-010-9422-6
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1807.
Date Backup
2010
Date Text
2010
DOI
10.1007/s10637-010-9422-6
Date Issued (EDTF)
2010
Extension


FAU
FAU
admin_unit="FAU01", ingest_id="ing11256", creator="creator:NBURWICK", creation_date="2011-10-26 15:36:21", modified_by="super:FAUDIG", modification_date="2014-02-12 10:36:47"

IID
FADT3318907
Issuance
single unit
Person Preferred Name

Guzman, Esther A.

creator

Physical Description

pdf
10 p.
PURL
http://purl.flvc.org/FCLA/DT/3318907
Title Plain
A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis
URL
http://purl.flvc.org/FCLA/DT/3318907
Origin Information

Springer Science+Business Media, LLC
2010
single unit
Title
A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis
Other Title Info

A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis