Note
by Anila Qureshi.
Member of
Contributors
Publisher
Florida Atlantic University
Date Issued
2012
Description
Soluble form of Junctional adhesion molecule C (sJAM-C) has been identified to cause angiogenesis as well as chemotaxis in endothelial cells. However, the role of sJAM-C in the context of cancer has not been elucidated. Our atomic force microscopy (AFM) stiffness measurements of normal mammary epithelial cells (MCF 10A) have shown a two-fold decrease in cell's stiffness in response to sJAM-C. Changes in cell stiffness are indicative of modulations in a cell's mechanical properties. Our results indicated that sJAM-C increased the MCF 10A cell migration about two-fold and also promoted a three-fold increase in chemotaxis. Additionally, sJAM-C treatment resulted in considerable filamentous-actin loss and peripheral actin ring breakage. We also found activation of Rho signaling pathway to be the main mechanism behind sJAM-C mediated alterations in MCF 10A cell cytoskeleton and motility. Our data present for the first time that sJAM-C is a pro metastatic mediator for normal mammary epithelial cells.
Language
Type
Form
Extent
vii, 40 p. : ill. (some col.)
Subject (Topical)
Identifier
856903285
OCLC Number
856903285
Additional Information
by Anila Qureshi.
Thesis (M.S.)--Florida Atlantic University, 2012.
Includes bibliography.
Mode of access: World Wide Web.
System requirements: Adobe Reader.
Date Backup
2012
Date Text
2012
Date Issued (EDTF)
2012
Extension
FAU
FAU
admin_unit="FAU01", ingest_id="ing15758", creator="creator:FAUDIG", creation_date="2013-08-22 10:41:02", modified_by="super:FAUDIG", modification_date="2013-08-26 11:36:05"
IID
FADT3362046
Organizations
Attributed name: Charles E. Schmidt College of Medicine
Attributed name: Department of Biomedical Science
Person Preferred Name
Qureshi, Anila
Graduate College
Physical Description
electronic
vii, 40 p. : ill. (some col.)
Title Plain
novel function of sJAM-C in promoting cytoskeleton rearrangement and migration in mammary epithelial cells
Use and Reproduction
http://rightsstatements.org/vocab/InC/1.0/
Origin Information
Boca Raton, Fla.
Florida Atlantic University
2012
Place
Boca Raton, Fla.
Title
novel function of sJAM-C in promoting cytoskeleton rearrangement and migration in mammary epithelial cells
Other Title Info
The
novel function of sJAM-C in promoting cytoskeleton rearrangement and migration in mammary epithelial cells