Polydiscamide A: a new bioactive depsipeptide from the marine sponge Discodermia sp.

A depsipeptide, polydiscamide A (1)) com& of 13 amino acids including a novel amino acid 3-methylisoleucine, was isolated from a Caribbean sponge, Discodermia sp. Its structure was elucidated by means of spectroscopic, chemical degradation, and derivatization techniques. Polydiscamide A inhibits the in vitro proliferation of the cultured human lung cancer A549 cell line.

This document is the accepted manuscript version of a published work that appeared in final form in The Journal of Organic Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo00032a031. This article may be cited as: Gulavita, N. K., Gunasekera, S. P., Pomponi, S. A., & Robinson, E. V. (1992). Polydiscamide A: a new bioactive depsipeptide from the marine sponge Discodermia sp. The Journal of Organic Chemistry, 57(6), 1767-1772. doi:10.1021/jo00032a031

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #880.