In addition to several known compounds related to puupehenone (11, three new congeners, including a ring-contracted variant, are described. One of these, 15-oxopuupehenol, shows significant differential antitumor and antimalarial activity.
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Organic Chemistry after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jo00127a039. This article may be cited as: Nasu, S. S., Young, B. K. S., Hamann, M. T., Scheuer, P. J., Kelly-Borges, M., & Goins, K. (1995). Puupehenone-related metabolites from two Hawaiian sponges, Hyrtios spp. Journal of Organic Chemistry, 60(22), 7290-7292. doi:10.1021/jo00127a039
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1110.