Quantitative structure-activity relationships (QSAR) were developed for a structurally diverse set of di- and triorganotin compounds. Correlations of the LC50 for mud crab zoeae, Rhithropanopeus harrisii, with the Hansch parameter, with the Leo fragment constant or with total surface area , TSA, a computed molecular topological value, yielded highly significant linear relationships. All the above parameters are indices of partitioning behaviour.
This manuscript may be cited as: Laughlin, Roy B., Jr. (1987). Quantitative structure-activity studies of di- and triorganotin compounds. In K. L. Kaiser (Ed.), QSAR in Environmental Toxicology - II. Proceedings of the 2nd International Workshop on QSAR in Environmental Toxicology, held at McMaster University, Hamilton, Ontario, Canada, June 9-13, 1986. (pp. 189-206). Dordrecht, The Netherlands: D. Reidel Publishing Co.
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #524.